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Acne-prone skin, atopic eczema, psoriasis-like murine, contact dermatitis, inflammatory scalp, diabetic wounds with persistent leukocyte infiltrate — all these contexts share a common denominator that hampers classical remodeling: chronic NF-κB activation, sustained release of TNF-α, IL-6, IL-1β, and a tissue microarchitecture disturbed by immune infiltrate

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But when mast cells release mediators too easily, too strongly, or at the wrong time, symptoms can appear across multiple systems