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Different viruses, including the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) 26 , influenza A virus (IAV) 21,27,28,29 , herpes simplex virus (HSV) 22 , hepatitis C virus (HCV) 30,31,32 , human immunodeficiency virus-1 (HIV-1) 33 , respiratory syncytial virus (RSV) 34 , and enterovirus (EV)-71 35 , induce ROS generation during infection

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The better understanding of the effect of how estrogen deficiency linked with the energy imbalance leads to lipid metabolic derangements promises to open a new novel clinical therapeutic strategy for an increasing large segment of the female population