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Jiangsu Hengrui Pharmaceuticals and Kailera Therapeutics report positive topline data from 8 mg dose of phase 2 obesity trial of GLP-1/GIP receptor dual agonist HRS9531

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The former can aggregate to form plaques and fibrils, which skew islet macrophages to a pro-inflammatory phenotype and induce IL-1β secretion in circulating monocyte-derived macrophages to facilitate their recruitment into the islet (71)