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Obsessive–compulsive disorder Similarities exist among brain regions implicated in addiction and obsessive–compulsive disorder (OCD), including the nucleus accumbens and anterior cingulate cortex.54,55 There have been reports of oxidative stress in populations with OCD, including increased lipid peroxidation;56–59 decreased vitamin E,58 catalase, GPx and selenium;59 increased superoxide dismutase;59 and changes in overall oxidative status.60 Some of these alterations have been linked to symptom severity.57,59 Standard first-line therapies for OCD generally include a combination of serotonin reuptake inhibitors (SRIs) and psychotherapy