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Additionally, another study demonstrated that AS-IV upregulates p-Akt/Akt and Bcl-2 expression in a concentration-dependent manner while downregulating pro-apoptotic proteins such as Bax and caspase-3, thereby mitigating I/R-induced apoptosis (Jia-lin et al., 2017)

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[DOI] [PMC free article] [PubMed] 38.Bonomini M., Pandolfi A., Di Liberato L., Di Silvestre S., Cnops Y., Di Tomo P., D'Arezzo M., Monaco M.P., Giardinelli A., Di Pietro N., et al