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Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway | Scientific Reports

In this work, the species-specific, pH-independent standard redox potentials of glutathione were determined primarily by comparing it to 1-methylnicotinamide, the simplest NAD + analogue

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This oxidized glutathione may then be reduced back to glutathione by glutathione reductase, although the process uses up NADPH in the process (Carmel-Harel and Storz, 2000, Öztetik, 2008, Mahmood et al., 2010, Foyer and Noctor, 2011, Noctor et al., 2012)