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A low-grade inflammation caused by obesity leads to its many inflammation-associated complications, including insulin resistance, type 2 diabetes, accelerated atherosclerosis, nonalcoholic steatohepatitis that can lead to liver cirrhosis, heart failure, cancer, and Alzheimer’s disease
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Mechanistic rationale, early observations, and emerging data can all contribute to discovery, but the translational challenge is understanding when those signals can be interpreted with enough confidence to support a medical decision
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